Glimepiride is used alongside a proper diet and exercise to manage type 2 diabetes mellitus (a condition characterized by high blood sugar levels) when metformin alone or in combination with other medications is not sufficient. It is not used to treat type 1 diabetes or diabetic ketoacidosis. Regular and proper use of this medication helps regulate blood sugar levels, prevent organ damage, and reduce the risk of complications such as heart, kidney, and brain diseases.